GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9815354 | 1 | rs1564716 | chr3:41862613 | ULK4 | chr3:41288091-42003660:- | 1 | 10.81 | 3.16E-18 | Diastolic blood pressure |
| THYM | cis | rs15676 | 1 | rs15676 | chr9:131572027 | ENDOG | chr9:131580779-131584954:+ | -0.24 | -4.96 | 3.05E-6 | Blood metabolite levels |
| THYM | cis | rs7849270 | 1 | rs1571229 | chr9:131913711 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs1577917 | 1 | rs1577917 | chr6:86691940 | SNHG5 | chr6:86386726-86388451:- | -0.61 | -7.35 | 6.78E-11 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs1577919 | chr6:86757296 | SNHG5 | chr6:86386726-86388451:- | -0.59 | -7.1 | 2.21E-10 | Response to antipsychotic treatment |
| THYM | cis | rs703842 | 1 | rs1599932 | chr12:58177943 | FAM119B | chr12:58166383-58176323:+ | 0.42 | 5.72 | 1.22E-7 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs1599932 | chr12:58177943 | TSFM | chr12:58176536-58191367:+ | -0.29 | -5.12 | 1.6E-6 | Multiple sclerosis |
| THYM | cis | rs2243480 | 1 | rs160633 | chr7:65528228 | CCT6P1 | chr7:65216092-65228661:+ | 0.65 | 5.41 | 4.64E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs160634 | chr7:65528664 | CCT6P1 | chr7:65216092-65228661:+ | -0.64 | -5.31 | 7.1E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs160637 | chr7:65584318 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 5.31 | 7.1E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs160639 | chr7:65579987 | CCT6P1 | chr7:65216092-65228661:+ | 0.63 | 5.27 | 8.65E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs160642 | chr7:65558373 | CCT6P1 | chr7:65216092-65228661:+ | 0.65 | 5.41 | 4.64E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs160643 | chr7:65558222 | CCT6P1 | chr7:65216092-65228661:+ | 0.67 | 5.68 | 1.48E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs160644 | chr7:65558186 | CCT6P1 | chr7:65216092-65228661:+ | 0.65 | 5.41 | 4.64E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs160646 | chr7:65556280 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 5.31 | 7.15E-7 | Diabetic kidney disease |